![]() In all five dogs, their echocardiographic indices of myocardial function were significantly improved after 3–6 months of taurine supplementation. A 2005 case series described taurine deficiency and DCM in five related golden retrievers fed commercial diets consisting of primarily lamb and rice or chicken and rice. It has long been recognized that while any breed is at risk of developing DCM secondary to taurine deficiency, certain dog breeds appear to be more susceptible than others, including the golden retriever. Within these breeds some investigations of association to taurine deficiency have been performed with results that did not clearly indicate any relationship to development of DCM. These include breeds like the Doberman Pinscher, Great Dane and Irish Wolfhound. In addition to nutritional etiologies of DCM, several dog breeds have been reported to have an inherited form of DCM. These studies suggested a direct causal link between taurine deficiency and the development of canine DCM. Subsequent studies revealed that when dogs with taurine deficiency and DCM were supplemented with taurine and L-carnitine, several of the myocardial changes resolved, and supportive cardiac medications were removed successfully in the vast majority of these dogs. In 1995, Kramer et al showed that a subset of dogs with DCM, in which golden retrievers and American cocker spaniels were overrepresented, had taurine deficiency. Less intuitive was the discovery that taurine deficiency also leads to DCM in the dog, despite the fact that taurine is not considered an essential amino acid in this species. Due to low enzyme activities of this pathway, which limit endogenous synthesis, taurine is nutritionally essential in the cat, and deficiency was easily and widely accepted as a direct cause of DCM in this species. In the dog, this sulfur-containing amino acid is synthesized primarily in the liver and central nervous system from methionine and cysteine via the transsulfuration pathway. Taurine deficiency and its association with dilated cardiomyopathy (DCM) is well described in the cat and dog. This does not alter our adherence to PLOS ONE policies on sharing data and materials. This did not lead to any conflict of interest or influence the collection or interpretation of results in this study. Fascetti is the Scientific Director of the Amino Acid Laboratory at the University of California, Davis that provides amino acid analysis on a fee for service basis. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the manuscript.įunding: The authors received no specific funding for this work.Ĭompeting interests: A.J. Received: AugAccepted: NovemPublished: December 13, 2018Ĭopyright: © 2018 Kaplan et al. Loor, University of Illinois, UNITED STATES (2018) Taurine deficiency and dilated cardiomyopathy in golden retrievers fed commercial diets. Citation: Kaplan JL, Stern JA, Fascetti AJ, Larsen JA, Skolnik H, Peddle GD, et al.
0 Comments
Leave a Reply. |